NASA's second human spaceflight program. Conducted between projects Mercury and Apollo, Gemini started in 1961 and concluded in 1966. The Gemini spacecraft carried a two-astronaut crew. Ten Gemini crews and 16 individual astronauts flew low Earth orbit (LEO) missions during 1965 and 1966.

Gemini's objective was the development of space travel techniques to support the Apollo mission to land astronauts on the Moon. In doing so, it allowed the United States to catch up and overcome the lead in human spaceflight capability the Soviet Union had obtained in the early years of the Space Race, by demonstrating: mission endurance up to just under 14 days, longer than the eight days required for a round trip to the Moon; methods of performing extra-vehicular activity (EVA) without tiring; and the orbital maneuvers necessary to achieve rendezvous and docking with another spacecraft. This left Apollo free to pursue its prime mission without spending time developing these techniques.

All Gemini flights were launched from Launch Complex 19 (LC-19) at Cape Kennedy Air Force Station in Florida. Their launch vehicle was the Gemini–Titan II, a modified Intercontinental Ballistic Missile (ICBM).

Gemini was the first program to use the newly built Mission Control Center at the Houston Manned Spacecraft Center for flight control.